HTLV1 Target gene Detail Information

> BLNK Gene Search Result

Gene Information

Gene Name	BLNK
Gene ID	29760
Gene Full Name	B cell linker
Gene Alias	bca; AGM4; BASH; LY57; SLP65; BLNK-S; SLP-65
Transcripts	ENSG00000095585
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Cytoplasmic bodies;Plasma membrane;
HPA Protein Class Info	Disease related genes, Predicted intracellular proteins
Gene Function	Suppressor gene
Uniport_ID	Q8WV28
HGNC ID	HGNC:14211
VEGA ID	OTTHUMG00000018827
OMIM ID	604515
String ID	9606.ENSP00000224337
PharmGKB ID	PA25371

Target gene [BLNK] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6004148	chr10	101	21	5	127	View
6004410	chr10	98	16	3	117	View
6015571	chr10	7	1	6	14	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of BLNK expression and immune infiltrating cell level correlation result in HTLV1+ samples
BLNK expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of BLNK expression and immune infiltrating cell level correlation result in HTLV1+ samples
BLNK expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of BLNK expression and immune infiltrating cell level correlation result in HTLV1+ samples
BLNK expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).