HIV Target gene Detail Information

> BLM Gene Search Result

Gene Information

Gene Name	BLM
Gene ID	641
Gene Full Name	BLM RecQ like helicase
Gene Alias	BS; RECQ2; RECQL2; RECQL3; MGRISCE1
Transcripts	ENSG00000197299
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;Cytosol;
HPA Protein Class Info	Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins
Gene Function	Suppressor gene
Uniport_ID	P54132
HGNC ID	HGNC:1058
VEGA ID	OTTHUMG00000149834
OMIM ID	604610
String ID	9606.ENSP00000347232
Drugbank ID	BE0001426
PharmGKB ID	PA25369

Target gene [BLM] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4000410	chr15	356	89	46	491	View
4003403	chr15	56	6		62	View
4005943	chr15	25	3		28	View
4009539	chr15	10		1	11	View
4010112	chr15	9	1		10	View
4012234	chr15	1	4		5	View
4014148	chr15	1	1		2	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of BLM expression and immune infiltrating cell level correlation result in HIV+ samples
BLM expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of BLM expression and immune infiltrating cell level correlation result in HIV+ samples
BLM expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).