Home
Virus
Gene
Disease
Dataset
Download
Help
 
HBV Target gene Detail Information

> BCL2 Gene Search Result


Gene Information
Gene Name BCL2
Gene ID 596
Gene Full Name BCL2, apoptosis regulator
Gene Alias Bcl-2; PPP1R50
Transcripts ENSG00000171791
Virus HBV
Gene Type protein coding
HPA Location Info Nuclear membrane;Nucleoplasm;
Membrane Info Predicted membrane proteins
HPA Protein Class Info Cancer-related genes, Disease related genes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Gene Function Oncogene
Uniport_ID P10415
HGNC ID HGNC:990
VEGA ID OTTHUMG00000132791
OMIM ID 151430
String ID 9606.ENSP00000381185
Drugbank ID BE0000246
PharmGKB ID PA25302
Target gene [BCL2] related to virus gene/protein/region
ID PMID Mutation Gene/Protein/Region Description Detail
1 29096158 G1764A
BCP
G
 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE114783 (GEO) Chronic HBV (CHB) infection 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Hepatocellular carcinoma 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Liver cirrhosis 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783

HeatMap of cell type fractions in all samples Lollipop of BCL2 expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
BCL2 expression: Low -> High
Lollipop of BCL2 expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples Lollipop of BCL2 expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of BCL2 expression and immune infiltrating cell level correlation result in HBV+ samples
BCL2 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).