HIV Target gene Detail Information

> BCKDHB Gene Search Result

Gene Information

Gene Name	BCKDHB
Gene ID	594
Gene Full Name	branched chain keto acid dehydrogenase E1 subunit beta
Gene Alias	E1B; BCKDE1B; BCKDH E1-beta
Transcripts	ENSG00000083123
Virus	HIV
Gene Type	protein coding
HPA Location Info	Mitochondria;Nucleoli;
HPA Protein Class Info	Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins
Gene Function	Oncogene
Uniport_ID	P21953
HGNC ID	HGNC:987
VEGA ID	OTTHUMG00000016430
OMIM ID	248611
String ID	9606.ENSP00000318351
PharmGKB ID	PA25298

Target gene [BCKDHB] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4004647	chr6	31		10	41	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of BCKDHB expression and immune infiltrating cell level correlation result in HIV+ samples
BCKDHB expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of BCKDHB expression and immune infiltrating cell level correlation result in HIV+ samples
BCKDHB expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).