HIV Target gene Detail Information

> AURKB Gene Search Result

Gene Information

Gene Name	AURKB
Gene ID	9212
Gene Full Name	aurora kinase B
Gene Alias	AIK2; AIM1; ARK2; AurB; IPL1; STK5; AIM-1; ARK-2; STK-1; STK12; PPP1R48; aurkb-sv1; aurkb-sv2
Transcripts	ENSG00000178999
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;Midbody;
HPA Protein Class Info	Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins
Uniport_ID	Q96GD4
HGNC ID	HGNC:11390
VEGA ID	OTTHUMG00000108189
OMIM ID	604970
String ID	9606.ENSP00000313950
Drugbank ID	BE0003404
PharmGKB ID	PA36199

Target gene [AURKB] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4002049	chr17	109	6		115	View
4004227	chr17	44	3		47	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of AURKB expression and immune infiltrating cell level correlation result in HIV+ samples
AURKB expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of AURKB expression and immune infiltrating cell level correlation result in HIV+ samples
AURKB expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).