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HTLV1 Target gene Detail Information

> ATOH8 Gene Search Result


Gene Information
Gene Name ATOH8
Gene ID 84913
Gene Full Name atonal bHLH transcription factor 8
Gene Alias HATH6; bHLHa21
Transcripts ENSG00000168874
Virus HTLV1
Gene Type protein coding
HPA Location Info Nucleoplasm;
HPA Protein Class Info Predicted intracellular proteins, Transcription factors
Uniport_ID Q96SQ7
HGNC ID HGNC:24126
VEGA ID OTTHUMG00000130178
String ID 9606.ENSP00000304676
PharmGKB ID PA134904746
Target gene [ATOH8] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
6004363 chr2 117 1 118 View
6004398 chr2 116 1 117 View
6100215 chr2 15 17 14 46 View
6100216 chr2 21 897 517 1435 View
6100217 chr2 213 213 View
6100218 chr2 66 30 2 98 View
6100219 chr2 847 357 480 1684 View
6100220 chr2 15 2 2 19 View
6100221 chr2 45 14 1 60 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE55851 (GEO) Adult T-cell leukemia 21 Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO) HTLV-1 associated myelopathy 39 Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO) HTLV-1 associated myelopathy 35 Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851

HeatMap of cell type fractions in all samples Lollipop of ATOH8 expression and immune infiltrating cell level correlation result in HTLV1+ samples
ATOH8 expression: Low -> High

> Dataset: GSE29312

HeatMap of cell type fractions in all samples Lollipop of ATOH8 expression and immune infiltrating cell level correlation result in HTLV1+ samples
ATOH8 expression: Low -> High

> Dataset: GSE29332

HeatMap of cell type fractions in all samples Lollipop of ATOH8 expression and immune infiltrating cell level correlation result in HTLV1+ samples
ATOH8 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).