HIV Target gene Detail Information

> ASXL1 Gene Search Result

Gene Information

Gene Name	ASXL1
Gene ID	171023
Gene Full Name	ASXL transcriptional regulator 1
Gene Alias	MDS; BOPS
Transcripts	ENSG00000171456
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nucleoli;Nucleoplasm;
HPA Protein Class Info	Cancer-related genes, Disease related genes, Predicted intracellular proteins
Gene Function	Suppressor gene
Uniport_ID	Q8IXJ9
HGNC ID	HGNC:18318
VEGA ID	OTTHUMG00000032218
OMIM ID	612990
String ID	9606.ENSP00000364839
PharmGKB ID	PA25078

Target gene [ASXL1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4002694	chr20	31	14	38	83	View
4004804	chr20	8	5	26	39	View
4006962	chr20	13	8		21	View
4008349	chr20	6	7	2	15	View
4008960	chr20	13			13	View
4010126	chr20	4	5	1	10	View
4012294	chr20	3	1	1	5	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of ASXL1 expression and immune infiltrating cell level correlation result in HIV+ samples
ASXL1 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of ASXL1 expression and immune infiltrating cell level correlation result in HIV+ samples
ASXL1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).