HTLV1 Target gene Detail Information

> ASTN1 Gene Search Result

Gene Information

Gene Name	ASTN1
Gene ID	460
Gene Full Name	astrotactin 1
Gene Alias	ASTN
Transcripts	ENSG00000152092
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Golgi apparatus;Vesicles;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Plasma proteins, Predicted membrane proteins, Transporters
Uniport_ID	O14525
HGNC ID	HGNC:773
VEGA ID	OTTHUMG00000035041
OMIM ID	600904
String ID	9606.ENSP00000354536
PharmGKB ID	PA162376961

Target gene [ASTN1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6017547	chr1	4	6		10	View
6023722	chr1	4			4	View
6026775	chr1	1	1		2	View
6027881	chr1	1			1	View
6030561	chr1				0	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of ASTN1 expression and immune infiltrating cell level correlation result in HTLV1+ samples
ASTN1 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of ASTN1 expression and immune infiltrating cell level correlation result in HTLV1+ samples
ASTN1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).