HTLV1 Target gene Detail Information

> ASNS Gene Search Result

Gene Information

Gene Name	ASNS
Gene ID	440
Gene Full Name	asparagine synthetase (glutamine-hydrolyzing)
Gene Alias	TS11; ASNSD
Transcripts	ENSG00000070669
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Cytosol;
HPA Protein Class Info	Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins
Uniport_ID	P08243
HGNC ID	HGNC:753
VEGA ID	OTTHUMG00000022892
OMIM ID	108370
String ID	9606.ENSP00000175506
Drugbank ID	BE0000219
PharmGKB ID	PA25052

Target gene [ASNS] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6000390	chr7	1747	34	11	1792	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of ASNS expression and immune infiltrating cell level correlation result in HTLV1+ samples
ASNS expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of ASNS expression and immune infiltrating cell level correlation result in HTLV1+ samples
ASNS expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of ASNS expression and immune infiltrating cell level correlation result in HTLV1+ samples
ASNS expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).