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HBV Target gene Detail Information

> ASGR2 Gene Search Result


Gene Information
Gene Name ASGR2
Gene ID 433
Gene Full Name asialoglycoprotein receptor 2
Gene Alias HL-2; HBXBP; ASGPR2; ASGP-R2; CLEC4H2
Transcripts ENSG00000161944
Virus HBV
Gene Type protein coding
HPA Location Info Endoplasmic reticulum;Plasma membrane;
Membrane Info Predicted membrane proteins
HPA Protein Class Info Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID P07307
HGNC ID HGNC:743
VEGA ID OTTHUMG00000102158
OMIM ID 108361
String ID 9606.ENSP00000347140
Drugbank ID BE0002118
PharmGKB ID PA25043
Target gene [ASGR2] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1003610 chr17 119 2 1 122 View
1004089 chr17 60 34 94 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE114783 (GEO) Chronic HBV (CHB) infection 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Hepatocellular carcinoma 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Liver cirrhosis 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783

HeatMap of cell type fractions in all samples Lollipop of ASGR2 expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
ASGR2 expression: Low -> High
Lollipop of ASGR2 expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples Lollipop of ASGR2 expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of ASGR2 expression and immune infiltrating cell level correlation result in HBV+ samples
ASGR2 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).