HTLV1 Target gene Detail Information

> ARL6IP5 Gene Search Result

Gene Information

Gene Name	ARL6IP5
Gene ID	10550
Gene Full Name	ADP ribosylation factor like GTPase 6 interacting protein 5
Gene Alias	JWA; jmx; hp22; PRAF3; Yip6b; DERP11; HSPC127; addicsin; GTRAP3-18
Transcripts	ENSG00000144746
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Endoplasmic reticulum;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Predicted membrane proteins, Transporters
Gene Function	Suppressor gene
Uniport_ID	O75915
HGNC ID	HGNC:16937
VEGA ID	OTTHUMG00000158773
OMIM ID	605709
String ID	9606.ENSP00000273258
PharmGKB ID	PA134898937

Target gene [ARL6IP5] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6010181	chr3	27	5		32	View
6010186	chr3	27	5		32	View
6010187	chr3	27	5		32	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of ARL6IP5 expression and immune infiltrating cell level correlation result in HTLV1+ samples
ARL6IP5 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of ARL6IP5 expression and immune infiltrating cell level correlation result in HTLV1+ samples
ARL6IP5 expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of ARL6IP5 expression and immune infiltrating cell level correlation result in HTLV1+ samples
ARL6IP5 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).