HIV Target gene Detail Information

> ARIH2 Gene Search Result

Gene Information

Gene Name	ARIH2
Gene ID	10425
Gene Full Name	ariadne RBR E3 ubiquitin protein ligase 2
Gene Alias	ARI2; TRIAD1
Transcripts	ENSG00000177479
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;
HPA Protein Class Info	Enzymes, Predicted intracellular proteins
Uniport_ID	O95376
HGNC ID	HGNC:690
VEGA ID	OTTHUMG00000133547
OMIM ID	605615
String ID	9606.ENSP00000348769
PharmGKB ID	PA24983

Target gene [ARIH2] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4000559	chr3	200	65	106	371	View
4000950	chr3	65	94	82	241	View
4000972	chr3	57	86	93	236	View
4001237	chr3	146	19	25	190	View
4001598	chr3	53	36	59	148	View
4002586	chr3	54	19	15	88	View
4002712	chr3	56	26	1	83	View
4002755	chr3	38	37	6	81	View
4010743	chr3	7	1		8	View
4011249	chr3	3		4	7	View
4011326	chr3	6	1		7	View
4015372	chr3		1		1	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of ARIH2 expression and immune infiltrating cell level correlation result in HIV+ samples
ARIH2 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of ARIH2 expression and immune infiltrating cell level correlation result in HIV+ samples
ARIH2 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).