HIV Target gene Detail Information

> ARHGEF6 Gene Search Result

Gene Information

Gene Name	ARHGEF6
Gene ID	9459
Gene Full Name	Rac/Cdc42 guanine nucleotide exchange factor 6
Gene Alias	PIXA; COOL2; MRX46; Cool-2; alphaPIX; alpha-PIX
Transcripts	ENSG00000129675
Virus	HIV
Gene Type	protein coding
HPA Location Info	Cytosol;
HPA Protein Class Info	Cancer-related genes, Disease related genes, Predicted intracellular proteins
Uniport_ID	Q15052
HGNC ID	HGNC:685
VEGA ID	OTTHUMG00000022518
OMIM ID	300267
String ID	9606.ENSP00000250617
PharmGKB ID	PA24976

Target gene [ARHGEF6] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4002165	chrX	28	69	11	108	View
4002680	chrX	82	2		84	View
4003467	chrX	56	3	2	61	View
4005768	chrX	2	28		30	View
4006001	chrX	28			28	View
4006133	chrX	27			27	View
4010621	chrX		8		8	View
4011940	chrX	6			6	View
4012521	chrX	5			5	View
4012791	chrX	2	2		4	View
4014034	chrX		3		3	View
4014582	chrX	2			2	View
4015160	chrX	1			1	View
4015161	chrX	1			1	View
4015568	chrX	1			1	View
4015727	chrX	1			1	View
4016461	chrX				0	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of ARHGEF6 expression and immune infiltrating cell level correlation result in HIV+ samples
ARHGEF6 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of ARHGEF6 expression and immune infiltrating cell level correlation result in HIV+ samples
ARHGEF6 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).