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HBV Target gene Detail Information

> ARHGEF3 Gene Search Result


Gene Information
Gene Name ARHGEF3
Gene ID 50650
Gene Full Name Rho guanine nucleotide exchange factor 3
Gene Alias GEF3; STA3; XPLN
Transcripts ENSG00000163947
Virus HBV
Gene Type protein coding
HPA Location Info Cytosol;
HPA Protein Class Info Predicted intracellular proteins
Uniport_ID Q9NR81
HGNC ID HGNC:683
VEGA ID OTTHUMG00000158857
OMIM ID 612115
String ID 9606.ENSP00000341071
PharmGKB ID PA24973
Target gene [ARHGEF3] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1001986 chr3 241 53 91 385 View
1005823 chr3 36 8 3 47 View
1012179 chr3 5 2 7 View
1012180 chr3 5 2 7 View
1012651 chr3 5 1 6 View
1012818 chr3 4 2 6 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE114783 (GEO) Chronic HBV (CHB) infection 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Hepatocellular carcinoma 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Liver cirrhosis 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783

HeatMap of cell type fractions in all samples Lollipop of ARHGEF3 expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
ARHGEF3 expression: Low -> High
Lollipop of ARHGEF3 expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples Lollipop of ARHGEF3 expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of ARHGEF3 expression and immune infiltrating cell level correlation result in HBV+ samples
ARHGEF3 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).