HIV Target gene Detail Information

> ARHGEF18 Gene Search Result

Gene Information

Gene Name	ARHGEF18
Gene ID	23370
Gene Full Name	Rho/Rac guanine nucleotide exchange factor 18
Gene Alias	RP78; P114-RhoGEF
Transcripts	ENSG00000104880
Virus	HIV
Gene Type	protein coding
HPA Location Info	Cytosol;
HPA Protein Class Info	Disease related genes, Predicted intracellular proteins
Uniport_ID	Q6ZSZ5
HGNC ID	HGNC:17090
VEGA ID	OTTHUMG00000177342
OMIM ID	616432
String ID	9606.ENSP00000352995
PharmGKB ID	PA128394630

Target gene [ARHGEF18] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4001610	chr19	89	30	28	147	View
4002085	chr19	35	52	26	113	View
4005788	chr19	27	2		29	View
4006298	chr19	23	3		26	View
4007800	chr19	16	1		17	View
4013394	chr19	3			3	View
4014922	chr19	1	1		2	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of ARHGEF18 expression and immune infiltrating cell level correlation result in HIV+ samples
ARHGEF18 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of ARHGEF18 expression and immune infiltrating cell level correlation result in HIV+ samples
ARHGEF18 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).