HBV Target gene Detail Information

> ARHGEF12 Gene Search Result

Gene Information

Gene Name	ARHGEF12
Gene ID	23365
Gene Full Name	Rho guanine nucleotide exchange factor 12
Gene Alias	LARG; PRO2792
Transcripts	ENSG00000196914
Virus	HBV
Gene Type	protein coding
HPA Location Info	Cytosol;Plasma membrane;Nucleoplasm;
HPA Protein Class Info	Cancer-related genes, Disease related genes, Predicted intracellular proteins
Gene Function	Suppressor gene
Uniport_ID	Q9NZN5
HGNC ID	HGNC:14193
VEGA ID	OTTHUMG00000166143
OMIM ID	604763
String ID	9606.ENSP00000380942
PharmGKB ID	PA24969

Target gene [ARHGEF12] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
1001923	chr11	46	256	116	418	View
1001924	chr11	46	256	116	418	View
1005681	chr11	37	12		49	View
1008840	chr11	18	1		19	View
1015944	chr11	2			2	View
1402769	chr11	37	12		49	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
LIHC (TCGA)	Liver hepatocellular carcinoma	424	Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: LIHC
HeatMap of cell type fractions in all samples	Lollipop of ARHGEF12 expression and immune infiltrating cell level correlation result in HBV+ samples
ARHGEF12 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).