HBV Target gene Detail Information

> ARHGEF10L Gene Search Result

Gene Information

Gene Name	ARHGEF10L
Gene ID	55160
Gene Full Name	Rho guanine nucleotide exchange factor 10 like
Gene Alias	GrinchGEF
Transcripts	ENSG00000074964
Virus	HBV
Gene Type	protein coding
HPA Location Info	Cytosol;Golgi apparatus;Vesicles;
HPA Protein Class Info	Predicted intracellular proteins
Uniport_ID	Q9HCE6
HGNC ID	HGNC:25540
VEGA ID	OTTHUMG00000002514
OMIM ID	612494
String ID	9606.ENSP00000355060
PharmGKB ID	PA142672586

Target gene [ARHGEF10L] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
1004760	chr1	63	1	6	70	View
1007714	chr1	24	1		25	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE114783 (GEO)	Chronic HBV (CHB) infection	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO)	Hepatocellular carcinoma	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO)	Liver cirrhosis	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA)	Liver hepatocellular carcinoma	424	Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783
HeatMap of cell type fractions in all samples	Lollipop of ARHGEF10L expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
ARHGEF10L expression: Low -> High
Lollipop of ARHGEF10L expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples	Lollipop of ARHGEF10L expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples


> Dataset: LIHC
HeatMap of cell type fractions in all samples	Lollipop of ARHGEF10L expression and immune infiltrating cell level correlation result in HBV+ samples
ARHGEF10L expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).