HTLV1 Target gene Detail Information

> ARHGAP22 Gene Search Result


Gene Information
Gene Name ARHGAP22
Gene ID 58504
Gene Full Name Rho GTPase activating protein 22
Gene Alias RhoGAP2; RhoGap22
Transcripts ENSG00000128805
Virus HTLV1
Gene Type protein coding
HPA Location Info Cytosol;Nucleoplasm;Plasma membrane;
HPA Protein Class Info Predicted intracellular proteins
Uniport_ID Q7Z5H3
HGNC ID HGNC:30320
VEGA ID OTTHUMG00000018176
OMIM ID 610585
String ID 9606.ENSP00000412461
PharmGKB ID PA134979724
Target gene [ARHGAP22] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
6007251 chr10 40 4 14 58 View
6011724 chr10 22 1 2 25 View
6032305 chr10 0 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE55851 (GEO) Adult T-cell leukemia 21 Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO) HTLV-1 associated myelopathy 39 Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO) HTLV-1 associated myelopathy 35 Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851

HeatMap of cell type fractions in all samples Lollipop of ARHGAP22 expression and immune infiltrating cell level correlation result in HTLV1+ samples
ARHGAP22 expression: Low -> High

> Dataset: GSE29312

HeatMap of cell type fractions in all samples Lollipop of ARHGAP22 expression and immune infiltrating cell level correlation result in HTLV1+ samples
ARHGAP22 expression: Low -> High

> Dataset: GSE29332

HeatMap of cell type fractions in all samples Lollipop of ARHGAP22 expression and immune infiltrating cell level correlation result in HTLV1+ samples
ARHGAP22 expression: Low -> High

Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).