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HTLV1 Target gene Detail Information

> AR Gene Search Result


Gene Information
Gene Name AR
Gene ID 367
Gene Full Name androgen receptor
Gene Alias KD; AIS; AR8; TFM; DHTR; SBMA; HYSP1; NR3C4; SMAX1; HUMARA
Transcripts ENSG00000169083
Virus HTLV1
Gene Type protein coding
HPA Location Info Cytosol;
HPA Protein Class Info Cancer-related genes, Disease related genes, FDA approved drug targets, Nuclear receptors, Plasma proteins, Predicted intracellular proteins, Transcription factors
Gene Function Oncogene
Uniport_ID P10275
HGNC ID HGNC:644
VEGA ID OTTHUMG00000021740
OMIM ID 313700
String ID 9606.ENSP00000363822
Drugbank ID BE0000132
PharmGKB ID PA57
Target gene [AR] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
6000769 chr16 671 163 38 872 View
6003402 chrX 101 26 35 162 View
6006781 chr3 14 32 17 63 View
6009097 chr16 25 13 1 39 View
6024456 chr19 2 1 3 View
6025515 chr21 3 3 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE55851 (GEO) Adult T-cell leukemia 21 Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO) HTLV-1 associated myelopathy 39 Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO) HTLV-1 associated myelopathy 35 Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851

HeatMap of cell type fractions in all samples Lollipop of AR expression and immune infiltrating cell level correlation result in HTLV1+ samples
AR expression: Low -> High

> Dataset: GSE29312

HeatMap of cell type fractions in all samples Lollipop of AR expression and immune infiltrating cell level correlation result in HTLV1+ samples
AR expression: Low -> High

> Dataset: GSE29332

HeatMap of cell type fractions in all samples Lollipop of AR expression and immune infiltrating cell level correlation result in HTLV1+ samples
AR expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).