HBV Target gene Detail Information

> APPL2 Gene Search Result

Gene Information

Gene Name	APPL2
Gene ID	55198
Gene Full Name	adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2
Gene Alias	DIP13B
Transcripts	ENSG00000136044
Virus	HBV
Gene Type	protein coding
HPA Location Info
HPA Protein Class Info	Disease related genes, Predicted intracellular proteins
Uniport_ID	Q8NEU8
HGNC ID	HGNC:18242
VEGA ID	OTTHUMG00000169853
OMIM ID	606231
String ID	9606.ENSP00000446917
PharmGKB ID	PA164741199

Target gene [APPL2] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
1014134	chr12	4			4	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
LIHC (TCGA)	Liver hepatocellular carcinoma	424	Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: LIHC
HeatMap of cell type fractions in all samples	Lollipop of APPL2 expression and immune infiltrating cell level correlation result in HBV+ samples
APPL2 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).