HIV Target gene Detail Information

> APPL1 Gene Search Result

Gene Information

Gene Name	APPL1
Gene ID	26060
Gene Full Name	adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1
Gene Alias	APPL; MODY14; DIP13alpha
Transcripts	ENSG00000157500
Virus	HIV
Gene Type	protein coding
HPA Location Info	Centrosome;Mitotic spindle;
HPA Protein Class Info	Disease related genes, Predicted intracellular proteins
Uniport_ID	Q9UKG1
HGNC ID	HGNC:24035
VEGA ID	OTTHUMG00000133756
OMIM ID	604299
String ID	9606.ENSP00000288266
PharmGKB ID	PA162376755

Target gene [APPL1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4005395	chr3	15	14	4	33	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of APPL1 expression and immune infiltrating cell level correlation result in HIV+ samples
APPL1 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of APPL1 expression and immune infiltrating cell level correlation result in HIV+ samples
APPL1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).