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HBV Target gene Detail Information

> APP Gene Search Result


Gene Information
Gene Name APP
Gene ID 351
Gene Full Name amyloid beta precursor protein
Gene Alias AAA; AD1; PN2; ABPP; APPI; CVAP; ABETA; PN-II; preA4; CTFgamma
Transcripts ENSG00000142192
Virus HBV
Gene Type protein coding
HPA Location Info Golgi apparatus;Vesicles;
Membrane Info Predicted membrane proteins
HPA Protein Class Info Disease related genes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Uniport_ID P05067
HGNC ID HGNC:620
VEGA ID OTTHUMG00000078438
OMIM ID 104760
String ID 9606.ENSP00000284981
Drugbank ID BE0003392
PharmGKB ID PA24910
Target gene [APP] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1006843 chr21 11 22 33 View
1007319 chr21 9 19 28 View
1404720 chr21 43 10 11 64 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of APP expression and immune infiltrating cell level correlation result in HBV+ samples
APP expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).