HIV Target gene Detail Information

> APOL1 Gene Search Result

Gene Information

Gene Name	APOL1
Gene ID	8542
Gene Full Name	apolipoprotein L1
Gene Alias	APOL; APO-L; FSGS4; APOL-I
Transcripts	ENSG00000100342
Virus	HIV
Gene Type	protein coding
HPA Location Info
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Candidate cardiovascular disease genes, Disease related genes, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins
Uniport_ID	O14791
HGNC ID	HGNC:618
VEGA ID	OTTHUMG00000030427
OMIM ID	603743
String ID	9606.ENSP00000317674
Drugbank ID	BE0008994
PharmGKB ID	PA24904

Target gene [APOL1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4010213	chr22	8		1	9	View
4010740	chr22	1	4	3	8	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of APOL1 expression and immune infiltrating cell level correlation result in HIV+ samples
APOL1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).