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HBV Target gene Detail Information

> APOE Gene Search Result


Gene Information
Gene Name APOE
Gene ID 348
Gene Full Name apolipoprotein E
Gene Alias AD2; LPG; APO-E; ApoE4; LDLCQ5
Transcripts ENSG00000130203
Virus HBV
Gene Type protein coding
HPA Location Info Vesicles;Predicted to be secreted;
HPA Protein Class Info Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Plasma proteins, Predicted secreted proteins
Uniport_ID P02649
HGNC ID HGNC:613
VEGA ID OTTHUMG00000128901
OMIM ID 107741
String ID 9606.ENSP00000252486
Drugbank ID BE0001119
PharmGKB ID PA55
Target gene [APOE] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1003305 chr19 95 54 7 156 View
1003355 chr19 91 52 7 150 View
1003824 chr19 72 28 6 106 View
1004354 chr19 49 31 4 84 View
1004933 chr19 56 6 3 65 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of APOE expression and immune infiltrating cell level correlation result in HBV+ samples
APOE expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).