HIV Target gene Detail Information

> APLP2 Gene Search Result

Gene Information

Gene Name	APLP2
Gene ID	334
Gene Full Name	amyloid beta precursor like protein 2
Gene Alias	APPH; APPL2; CDEBP; APLP-2
Transcripts	ENSG00000084234
Virus	HIV
Gene Type	protein coding
HPA Location Info	Vesicles;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID	Q06481
HGNC ID	HGNC:598
VEGA ID	OTTHUMG00000165767
OMIM ID	104776
String ID	9606.ENSP00000263574
Drugbank ID	BE0009018; BE0009093
PharmGKB ID	PA24885

Target gene [APLP2] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4011181	chr11	7			7	View
4011182	chr11	7			7	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of APLP2 expression and immune infiltrating cell level correlation result in HIV+ samples
APLP2 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of APLP2 expression and immune infiltrating cell level correlation result in HIV+ samples
APLP2 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).