HTLV1 Target gene Detail Information

> AP4B1 Gene Search Result

Gene Information

Gene Name	AP4B1
Gene ID	10717
Gene Full Name	adaptor related protein complex 4 subunit beta 1
Gene Alias	CPSQ5; SPG47; BETA-4
Transcripts	ENSG00000134262
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Vesicles;
HPA Protein Class Info	Disease related genes, Predicted intracellular proteins
Uniport_ID	Q9Y6B7
HGNC ID	HGNC:572
VEGA ID	OTTHUMG00000011943
OMIM ID	607245
String ID	9606.ENSP00000358582
PharmGKB ID	PA24864

Target gene [AP4B1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6000065	chr1	996	2628	2080	5704	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of AP4B1 expression and immune infiltrating cell level correlation result in HTLV1+ samples
AP4B1 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of AP4B1 expression and immune infiltrating cell level correlation result in HTLV1+ samples
AP4B1 expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of AP4B1 expression and immune infiltrating cell level correlation result in HTLV1+ samples
AP4B1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).