HIV Target gene Detail Information

> ANXA1 Gene Search Result

Gene Information

Gene Name	ANXA1
Gene ID	301
Gene Full Name	annexin A1
Gene Alias	ANX1; LPC1
Transcripts	ENSG00000135046
Virus	HIV
Gene Type	protein coding
HPA Location Info	Cytosol;Plasma membrane;Nucleoplasm;Predicted to be secreted;
HPA Protein Class Info	Cancer-related genes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins, Transporters
Gene Function	Suppressor gene
Uniport_ID	P04083
HGNC ID	HGNC:533
VEGA ID	OTTHUMG00000020016
OMIM ID	151690
String ID	9606.ENSP00000366109
Drugbank ID	BE0000422
PharmGKB ID	PA24823

Target gene [ANXA1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4015716	chr9	1			1	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of ANXA1 expression and immune infiltrating cell level correlation result in HIV+ samples
ANXA1 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of ANXA1 expression and immune infiltrating cell level correlation result in HIV+ samples
ANXA1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).