HTLV1 Target gene Detail Information

> ANKLE2 Gene Search Result

Gene Information

Gene Name	ANKLE2
Gene ID	23141
Gene Full Name	ankyrin repeat and LEM domain containing 2
Gene Alias	Lem4; LEMD7; MCPH16; KIAA0692
Transcripts	ENSG00000176915
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Endoplasmic reticulum;Plasma membrane;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Disease related genes, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID	Q86XL3
HGNC ID	HGNC:29101
VEGA ID	OTTHUMG00000168046
OMIM ID	616062
String ID	9606.ENSP00000350686
PharmGKB ID	PA162376532

Target gene [ANKLE2] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6025205	chr12	3			3	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of ANKLE2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
ANKLE2 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).