HTLV1 Target gene Detail Information

> ALPK1 Gene Search Result

Gene Information

Gene Name	ALPK1
Gene ID	80216
Gene Full Name	alpha kinase 1
Gene Alias	LAK; 8430410J10Rik
Transcripts	ENSG00000073331
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Centrosome;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Enzymes, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID	Q96QP1
HGNC ID	HGNC:20917
VEGA ID	OTTHUMG00000132911
OMIM ID	607347
String ID	9606.ENSP00000398048
PharmGKB ID	PA134891785

Target gene [ALPK1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6000935	chr4	511	128	56	695	View
6000936	chr4	511	128	56	695	View
6000942	chr4	511	128	52	691	View
6002437	chr4	189	18	35	242	View
6014308	chr4	1	13	3	17	View
6019571	chr4	8			8	View
6022289	chr4	1	4		5	View
6029702	chr4	1			1	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of ALPK1 expression and immune infiltrating cell level correlation result in HTLV1+ samples
ALPK1 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of ALPK1 expression and immune infiltrating cell level correlation result in HTLV1+ samples
ALPK1 expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of ALPK1 expression and immune infiltrating cell level correlation result in HTLV1+ samples
ALPK1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).