HTLV1 Target gene Detail Information

> ALDH2 Gene Search Result

Gene Information

Gene Name	ALDH2
Gene ID	217
Gene Full Name	aldehyde dehydrogenase 2 family member
Gene Alias	ALDM; ALDHI; ALDH-E2
Transcripts	ENSG00000111275
Virus	HTLV1
Gene Type	protein coding
HPA Location Info
HPA Protein Class Info	Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins
Uniport_ID	P05091
HGNC ID	HGNC:404
VEGA ID	OTTHUMG00000169603
OMIM ID	100650
String ID	9606.ENSP00000261733
Drugbank ID	BE0000133
PharmGKB ID	PA24696

Target gene [ALDH2] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6003401	chr12	48	37	77	162	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of ALDH2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
ALDH2 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of ALDH2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
ALDH2 expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of ALDH2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
ALDH2 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).