HTLV1 Target gene Detail Information

> ALAS1 Gene Search Result

Gene Information

Gene Name	ALAS1
Gene ID	211
Gene Full Name	5'-aminolevulinate synthase 1
Gene Alias	ALAS; MIG4; ALAS3; ALASH; ALAS-H
Transcripts	ENSG00000023330
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Mitochondria;Nucleoplasm;
HPA Protein Class Info	Enzymes, Plasma proteins, Predicted intracellular proteins
Uniport_ID	P13196
HGNC ID	HGNC:396
VEGA ID	OTTHUMG00000158108
OMIM ID	125290
String ID	9606.ENSP00000378416
Drugbank ID	BE0000409; BE0002158
PharmGKB ID	PA24688

Target gene [ALAS1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6008307	chr3	46			46	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of ALAS1 expression and immune infiltrating cell level correlation result in HTLV1+ samples
ALAS1 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of ALAS1 expression and immune infiltrating cell level correlation result in HTLV1+ samples
ALAS1 expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of ALAS1 expression and immune infiltrating cell level correlation result in HTLV1+ samples
ALAS1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).