HIV Target gene Detail Information

> AKT2 Gene Search Result

Gene Information

Gene Name	AKT2
Gene ID	208
Gene Full Name	AKT serine/threonine kinase 2
Gene Alias	PKBB; PRKBB; HIHGHH; PKBBETA; RAC-BETA
Transcripts	ENSG00000105221
Virus	HIV
Gene Type	protein coding
HPA Location Info	Cytosol;Nucleoplasm;Vesicles;
HPA Protein Class Info	Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, RAS pathway related proteins
Gene Function	Oncogene
Uniport_ID	P31751
HGNC ID	HGNC:392
VEGA ID	OTTHUMG00000137375
OMIM ID	164731
String ID	9606.ENSP00000375892
Drugbank ID	BE0001172
PharmGKB ID	PA24685

Target gene [AKT2] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4001213	chr19	4	128	61	193	View
4006059	chr19	20	2	5	27	View
4016505	chr19				0	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of AKT2 expression and immune infiltrating cell level correlation result in HIV+ samples
AKT2 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).