HBV Target gene Detail Information

> AKR1C4 Gene Search Result

Gene Information

Gene Name	AKR1C4
Gene ID	1109
Gene Full Name	aldo-keto reductase family 1 member C4
Gene Alias	C11; CDR; DD4; CHDR; DD-4; HAKRA; 3-alpha-HSD
Transcripts	ENSG00000198610
Virus	HBV
Gene Type	protein coding
HPA Location Info	Cytosol;Nucleoplasm;Endoplasmic reticulum;Nucleoli fibrillar center;
HPA Protein Class Info	Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins
Uniport_ID	P17516
HGNC ID	HGNC:387
VEGA ID	OTTHUMG00000017591
OMIM ID	600451
String ID	9606.ENSP00000369814
Drugbank ID	BE0000438
PharmGKB ID	PA24680

Target gene [AKR1C4] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
1007074	chr10	25	6		31	View
1017248	chr10	1			1	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
LIHC (TCGA)	Liver hepatocellular carcinoma	424	Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: LIHC
HeatMap of cell type fractions in all samples	Lollipop of AKR1C4 expression and immune infiltrating cell level correlation result in HBV+ samples
AKR1C4 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).