HBV Target gene Detail Information

> AKR1C3 Gene Search Result

Gene Information

Gene Name	AKR1C3
Gene ID	8644
Gene Full Name	aldo-keto reductase family 1 member C3
Gene Alias	DD3; DDX; PGFS; HAKRB; HAKRe; HA1753; HSD17B5; hluPGFS
Transcripts	ENSG00000196139
Virus	HBV
Gene Type	protein coding
HPA Location Info	Cytosol;Nucleoplasm;Endoplasmic reticulum;Nucleoli fibrillar center;
HPA Protein Class Info	Enzymes, Plasma proteins, Predicted intracellular proteins
Uniport_ID	P42330
HGNC ID	HGNC:386
VEGA ID	OTTHUMG00000017585
OMIM ID	603966
String ID	9606.ENSP00000369927
Drugbank ID	BE0000592
PharmGKB ID	PA24679

Target gene [AKR1C3] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
1000685	chr10	301	814	491	1606	View
1015468	chr10	2			2	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
LIHC (TCGA)	Liver hepatocellular carcinoma	424	Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: LIHC
HeatMap of cell type fractions in all samples	Lollipop of AKR1C3 expression and immune infiltrating cell level correlation result in HBV+ samples
AKR1C3 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).