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HBV Target gene Detail Information

> AKR1C2 Gene Search Result


Gene Information
Gene Name AKR1C2
Gene ID 1646
Gene Full Name aldo-keto reductase family 1 member C2
Gene Alias DD; DD2; TDD; BABP; DD-2; DDH2; HBAB; HAKRD; MCDR2; SRXY8; DD/BABP; AKR1C-pseudo
Transcripts ENSG00000151632
Virus HBV
Gene Type protein coding
HPA Location Info Cytosol;Nucleoplasm;Endoplasmic reticulum;Nucleoli fibrillar center;
HPA Protein Class Info Disease related genes, Enzymes, FDA approved drug targets, Predicted intracellular proteins
Uniport_ID P52895
HGNC ID HGNC:385
VEGA ID OTTHUMG00000017584
OMIM ID 600450
String ID 9606.ENSP00000370129
Drugbank ID BE0000622
PharmGKB ID PA24678
Target gene [AKR1C2] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1004673 chr10 50 13 9 72 View
1402928 chr10 50 13 9 72 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of AKR1C2 expression and immune infiltrating cell level correlation result in HBV+ samples
AKR1C2 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).