HIV Target gene Detail Information

> AKAP8L Gene Search Result

Gene Information

Gene Name	AKAP8L
Gene ID	26993
Gene Full Name	A-kinase anchoring protein 8 like
Gene Alias	HA95; HAP95; NAKAP; NAKAP95
Transcripts	ENSG00000011243
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nuclear speckles;
HPA Protein Class Info	Predicted intracellular proteins
Uniport_ID	Q9ULX6
HGNC ID	HGNC:29857
VEGA ID	OTTHUMG00000182446
OMIM ID	609475
String ID	9606.ENSP00000380557
PharmGKB ID	PA134867364

Target gene [AKAP8L] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4002594	chr19	83	5		88	View
4005068	chr19	12	22	2	36	View
4009384	chr19	5	4	3	12	View
4011074	chr19	3	2	2	7	View
4011525	chr19	5	1		6	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of AKAP8L expression and immune infiltrating cell level correlation result in HIV+ samples
AKAP8L expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of AKAP8L expression and immune infiltrating cell level correlation result in HIV+ samples
AKAP8L expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).