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HIV Target gene Detail Information

> AK2 Gene Search Result


Gene Information
Gene Name AK2
Gene ID 204
Gene Full Name adenylate kinase 2
Gene Alias ADK2
Transcripts ENSG00000004455
Virus HIV
Gene Type protein coding
HPA Location Info Mitochondria;
HPA Protein Class Info Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins
Uniport_ID P54819
HGNC ID HGNC:362
VEGA ID OTTHUMG00000004131
OMIM ID 103020
String ID 9606.ENSP00000346921
Drugbank ID BE0004477
PharmGKB ID PA24656
Target gene [AK2] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
4001008 chr2 212 5 12 229 View
4001510 chr3 123 27 6 156 View
4001511 chr3 123 27 6 156 View
4002839 chr3 57 15 6 78 View
4002880 chr2 17 20 39 76 View
4002960 chr3 56 12 6 74 View
4003557 chr9 16 43 59 View
4003772 chr3 55 55 View
4003773 chr3 55 55 View
4003774 chr3 55 55 View
4003832 chr3 54 54 View
4003833 chr3 54 54 View
4003891 chr2 50 3 53 View
4005582 chr9 31 31 View
4005638 chr3 22 9 31 View
4005918 chr3 23 5 28 View
4006082 chr2 13 13 1 27 View
4007031 chr1 9 6 6 21 View
4007094 chr9 1 20 21 View
4007156 chr9 21 21 View
4008170 chr3 16 16 View
4011097 chr3 6 1 7 View
4012367 chr9 3 2 5 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE17372 (GEO) AIDS-associated lymphoma 17 AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO) HIV-infected disease 44 HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372

HeatMap of cell type fractions in all samples Lollipop of AK2 expression and immune infiltrating cell level correlation result in HIV+ samples
AK2 expression: Low -> High

> Dataset: GSE50834

HeatMap of cell type fractions in all samples Lollipop of AK2 expression and immune infiltrating cell level correlation result in HIV+ samples
AK2 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).