HBV Target gene Detail Information

> AK1 Gene Search Result

Gene Information

Gene Name	AK1
Gene ID	203
Gene Full Name	adenylate kinase 1
Gene Alias	HTL-S-58j
Transcripts	ENSG00000106992
Virus	HBV
Gene Type	protein coding
HPA Location Info	Cytosol;
HPA Protein Class Info	Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins
Uniport_ID	P00568
HGNC ID	HGNC:361
VEGA ID	OTTHUMG00000020722
OMIM ID	103000
String ID	9606.ENSP00000362271
Drugbank ID	BE0001262
PharmGKB ID	PA24655

Target gene [AK1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
1002702	chr2	216	4		220	View
1003023	chr12	137	31	6	174	View
1003384	chr15	99	28	11	138	View
1006921	chr12	4	10	18	32	View
1011529	chr3	8	1		9	View
1403216	chr9	25	8	6	39	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE114783 (GEO)	Chronic HBV (CHB) infection	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO)	Hepatocellular carcinoma	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO)	Liver cirrhosis	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA)	Liver hepatocellular carcinoma	424	Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783
HeatMap of cell type fractions in all samples	Lollipop of AK1 expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
AK1 expression: Low -> High
Lollipop of AK1 expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples	Lollipop of AK1 expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples


> Dataset: LIHC
HeatMap of cell type fractions in all samples	Lollipop of AK1 expression and immune infiltrating cell level correlation result in HBV+ samples
AK1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).