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HTLV1 Target gene Detail Information

> AGRN Gene Search Result


Gene Information
Gene Name AGRN
Gene ID 375790
Gene Full Name agrin
Gene Alias CMS8; AGRIN; CMSPPD
Transcripts ENSG00000188157
Virus HTLV1
Gene Type protein coding
HPA Location Info Cytosol;Plasma membrane;Predicted to be secreted;
Membrane Info Predicted membrane proteins
HPA Protein Class Info Disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins
Gene Function Oncogene
Uniport_ID O00468
HGNC ID HGNC:329
VEGA ID OTTHUMG00000040778
OMIM ID 103320
String ID 9606.ENSP00000368678
PharmGKB ID PA24626
Target gene [AGRN] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
6007596 chr1 32 21 53 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE55851 (GEO) Adult T-cell leukemia 21 Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO) HTLV-1 associated myelopathy 39 Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO) HTLV-1 associated myelopathy 35 Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851

HeatMap of cell type fractions in all samples Lollipop of AGRN expression and immune infiltrating cell level correlation result in HTLV1+ samples
AGRN expression: Low -> High

> Dataset: GSE29312

HeatMap of cell type fractions in all samples Lollipop of AGRN expression and immune infiltrating cell level correlation result in HTLV1+ samples
AGRN expression: Low -> High

> Dataset: GSE29332

HeatMap of cell type fractions in all samples Lollipop of AGRN expression and immune infiltrating cell level correlation result in HTLV1+ samples
AGRN expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).