HIV Target gene Detail Information

> AGER Gene Search Result

Gene Information

Gene Name	AGER
Gene ID	177
Gene Full Name	advanced glycosylation end-product specific receptor
Gene Alias	RAGE; SCARJ1
Transcripts	ENSG00000230514
Virus	HIV
Gene Type	protein coding
HPA Location Info	Cell Junctions;Plasma membrane;Nucleoli fibrillar center;Predicted to be secreted;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Cancer-related genes, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins
Uniport_ID	Q15109
HGNC ID	HGNC:320
VEGA ID	OTTHUMG00000012746
OMIM ID	600214
String ID	9606.ENSP00000364210
PharmGKB ID	PA24617

Target gene [AGER] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4002922	chr6	75			75	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of AGER expression and immune infiltrating cell level correlation result in HIV+ samples
AGER expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of AGER expression and immune infiltrating cell level correlation result in HIV+ samples
AGER expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).