HBV Target gene Detail Information

> AFP Gene Search Result

Gene Information

Gene Name	AFP
Gene ID	174
Gene Full Name	alpha fetoprotein
Gene Alias	AFPD; FETA; HPAFP
Transcripts	ENSG00000081051
Virus	HBV
Gene Type	protein coding
HPA Location Info	Golgi apparatus;Cytosol;Predicted to be secreted;
HPA Protein Class Info	Cancer-related genes, Disease related genes, Plasma proteins, Predicted secreted proteins
Uniport_ID	P02771
HGNC ID	HGNC:317
VEGA ID	OTTHUMG00000130011
OMIM ID	104150
String ID	9606.ENSP00000379138
Drugbank ID	BE0009318
PharmGKB ID	PA24614

Target gene [AFP] related to virus gene/protein/region

ID	PMID	Mutation	Gene/Protein/Region	Description	Detail
1	18647234	Q179K	C	R	View
2	23805180	A1762T	BCP	C	View
3	25501679	C2964A	PreS1	C	View
4	29479565	A2189C	C	C	View
5	29479565	G1764A	BCP	C	View
6	29628773	A1762T	BCP	C	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
LIHC (TCGA)	Liver hepatocellular carcinoma	424	Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: LIHC
HeatMap of cell type fractions in all samples	Lollipop of AFP expression and immune infiltrating cell level correlation result in HBV+ samples
AFP expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).