HBV Target gene Detail Information

> ADK Gene Search Result

Gene Information

Gene Name	ADK
Gene ID	132
Gene Full Name	adenosine kinase
Gene Alias	AK
Transcripts	ENSG00000156110
Virus	HBV
Gene Type	protein coding
HPA Location Info	Cytosol;Nucleoplasm;Plasma membrane;
HPA Protein Class Info	Disease related genes, Enzymes, FDA approved drug targets, Predicted intracellular proteins
Uniport_ID	P55263
HGNC ID	HGNC:257
VEGA ID	OTTHUMG00000018506
OMIM ID	102750
String ID	9606.ENSP00000286621
Drugbank ID	BE0003540; BE0001237; BE0001244; BE0001254; BE0001255
PharmGKB ID	PA24579

Target gene [ADK] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
1000491	chr1	1843	99	136	2078	View
1017951	chr10				0	View
1401161	chr10				0	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE114783 (GEO)	Chronic HBV (CHB) infection	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO)	Hepatocellular carcinoma	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO)	Liver cirrhosis	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA)	Liver hepatocellular carcinoma	424	Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783
HeatMap of cell type fractions in all samples	Lollipop of ADK expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
ADK expression: Low -> High
Lollipop of ADK expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples	Lollipop of ADK expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples


> Dataset: LIHC
HeatMap of cell type fractions in all samples	Lollipop of ADK expression and immune infiltrating cell level correlation result in HBV+ samples
ADK expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).