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HBV Target gene Detail Information

> ADCY3 Gene Search Result


Gene Information
Gene Name ADCY3
Gene ID 109
Gene Full Name adenylate cyclase 3
Gene Alias AC3; AC-III; BMIQ19
Transcripts ENSG00000138031
Virus HBV
Gene Type protein coding
HPA Location Info
Membrane Info Predicted membrane proteins
HPA Protein Class Info Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID O60266
HGNC ID HGNC:234
VEGA ID OTTHUMG00000094765
OMIM ID 600291
String ID 9606.ENSP00000260600
PharmGKB ID PA164741137
Target gene [ADCY3] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1003294 chr2 117 24 7 148 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE114783 (GEO) Chronic HBV (CHB) infection 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Hepatocellular carcinoma 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Liver cirrhosis 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783

HeatMap of cell type fractions in all samples Lollipop of ADCY3 expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
ADCY3 expression: Low -> High
Lollipop of ADCY3 expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples Lollipop of ADCY3 expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of ADCY3 expression and immune infiltrating cell level correlation result in HBV+ samples
ADCY3 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).