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HPV Target gene Detail Information

> ADAM28 Gene Search Result


Gene Information
Gene Name ADAM28
Gene ID 10863
Gene Full Name ADAM metallopeptidase domain 28
Gene Alias MDCL; MDC-L; eMDCII; ADAM 28; eMDC II
Transcripts ENSG00000042980
Virus HPV
Gene Type protein coding
HPA Location Info Plasma membrane;Mitochondria;Predicted to be secreted;
Membrane Info Predicted membrane proteins
HPA Protein Class Info Plasma proteins, Predicted membrane proteins, Predicted secreted proteins, Transporters
Gene Function Oncogene
Uniport_ID Q9UKQ2
HGNC ID HGNC:206
VEGA ID OTTHUMG00000163780
OMIM ID 606188
String ID 9606.ENSP00000265769
Drugbank ID BE0003872
PharmGKB ID PA24523
Target gene [ADAM28] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
5200382 chr8 27 6 1 34 View
5404641 chr8 1 1 2 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE140662 (GEO) Condyloma Acuminatum 8 Condyloma acuminata (HPV+)(5), Skin(3)
GSE65858 (GEO) Head and neck squamous cell carcinoma 270 Head and neck squamous cell carcinoma (EBV+)(73), Head and neck squamous cell carcinoma (EBV-)(197)
GSE40774 (GEO) Head and neck squamous cell carcinoma 134 Head and neck Squamous cell carcinomas GLOTTIC LARYNX (EBV-)(2), Head and neck Squamous cell carcinomas HYPOPHARYNX (EBV-)(9), Head and neck Squamous cell carcinomas ORAL CAVITY (EBV-)(23), Head and neck Squamous cell carcinomas ORAL CAVITY (EBV+)(2), Head and neck Squamous cell carcinomas OROPHARYNX (EBV-)(22), Head and neck Squamous cell carcinomas OROPHARYNX (EBV+)(54), Head and neck Squamous cell carcinomas OTHER (EBV+)(1), Head and neck Squamous cell carcinomas SUBGLOTTIC LARYNX (EBV-)(1), Head and neck Squamous cell carcinomas SUPRAGLOTTIC (EBV-)(19), Squamous cell carcinomas SUPRAGLOTTIC (EBV+)(1)
GSE55546 (GEO) Oropharyngeal squamous cell carcinoma 16 Oropharyngeal cancers (HPV+)(12), Normal (4)
GSE55544 (GEO) Oropharyngeal squamous cell carcinoma 23 Oropharyngeal cancers HPV Active (11), Oropharyngeal cancers HPV Inactive (4), Oropharyngeal cancers HPV Negative (8)
GSE55542 (GEO) Oropharyngeal squamous cell carcinoma 36 Oropharyngeal cancers HPV Active (12), Oropharyngeal cancers HPV Inactive (8), Oropharyngeal cancers HPV Negative (16)
GSE138080 (GEO) Cervical intraepithelial neoplasia 25 Normal (10), Cervical intraepithelial neoplasia (HPV+)(15)
GSE51993 (GEO) Cervical intraepithelial neoplasia 24 Cervical intraepithelial neoplasia (HPV+)(17), Normal(7)
HNSC (TCGA) Head and Neck squamous cell carcinoma 566 Head and Neck squamous cell carcinoma(HPV-)(483),Head and Neck squamous cell carcinoma(HPV+)(39),Paracancerous(HPV-)(44)

> Dataset: GSE140662

HeatMap of cell type fractions in all samples Lollipop of ADAM28 expression and immune infiltrating cell level correlation result in HPV+ samples
ADAM28 expression: Low -> High

> Dataset: GSE65858

HeatMap of cell type fractions in all samples Lollipop of ADAM28 expression and immune infiltrating cell level correlation result in HPV+ samples
ADAM28 expression: Low -> High

> Dataset: GSE40774

HeatMap of cell type fractions in all samples Lollipop of ADAM28 expression and immune infiltrating cell level correlation result in HPV+ samples
ADAM28 expression: Low -> High

> Dataset: GSE55546

HeatMap of cell type fractions in all samples Lollipop of ADAM28 expression and immune infiltrating cell level correlation result in HPV+ samples
ADAM28 expression: Low -> High

> Dataset: GSE55544

HeatMap of cell type fractions in all samples Lollipop of ADAM28 expression and immune infiltrating cell level correlation result in HPV+ samples
ADAM28 expression: Low -> High

> Dataset: GSE55542

HeatMap of cell type fractions in all samples Lollipop of ADAM28 expression and immune infiltrating cell level correlation result in HPV+ samples
ADAM28 expression: Low -> High

> Dataset: GSE138080

HeatMap of cell type fractions in all samples Lollipop of ADAM28 expression and immune infiltrating cell level correlation result in HPV+ samples
ADAM28 expression: Low -> High

> Dataset: GSE51993

HeatMap of cell type fractions in all samples Lollipop of ADAM28 expression and immune infiltrating cell level correlation result in HPV+ samples
ADAM28 expression: Low -> High

> Dataset: HNSC

HeatMap of cell type fractions in all samples Lollipop of ADAM28 expression and immune infiltrating cell level correlation result in HPV+ samples
ADAM28 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).