HBV Target gene Detail Information

> ADAM17 Gene Search Result

Gene Information

Gene Name	ADAM17
Gene ID	6868
Gene Full Name	ADAM metallopeptidase domain 17
Gene Alias	CSVP; TACE; NISBD; ADAM18; CD156B; NISBD1
Transcripts	ENSG00000151694
Virus	HBV
Gene Type	protein coding
HPA Location Info	Cytosol;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	CD markers, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Uniport_ID	P78536
HGNC ID	HGNC:195
VEGA ID	OTTHUMG00000090425
OMIM ID	603639
String ID	9606.ENSP00000309968
Drugbank ID	BE0003754
PharmGKB ID	PA24512

Target gene [ADAM17] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
1008209	chr2	9	6	7	22	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
LIHC (TCGA)	Liver hepatocellular carcinoma	424	Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: LIHC
HeatMap of cell type fractions in all samples	Lollipop of ADAM17 expression and immune infiltrating cell level correlation result in HBV+ samples
ADAM17 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).