HIV Target gene Detail Information

> ADA Gene Search Result

Gene Information

Gene Name	ADA
Gene ID	100
Gene Full Name	adenosine deaminase
Transcripts	ENSG00000196839
Virus	HIV
Gene Type	protein coding
HPA Location Info	Plasma membrane;Cytosol;
HPA Protein Class Info	Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins
Uniport_ID	P00813
HGNC ID	HGNC:186
VEGA ID	OTTHUMG00000033081
OMIM ID	608958
String ID	9606.ENSP00000361965
Drugbank ID	BE0002214
PharmGKB ID	PA24503

Target gene [ADA] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4004201	chr2	38	9	1	48	View
4004975	chr2	37			37	View
4005228	chr2	24	9	2	35	View
4005486	chr2	11	9	12	32	View
4006241	chr20	20	5	1	26	View
4009104	chr2	6		6	12	View
4009153	chr20	9	2	1	12	View
4009357	chr17	11	1		12	View
4012259	chr17	3	2		5	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of ADA expression and immune infiltrating cell level correlation result in HIV+ samples
ADA expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of ADA expression and immune infiltrating cell level correlation result in HIV+ samples
ADA expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).