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HPV Target gene Detail Information

> ACVR2A Gene Search Result


Gene Information
Gene Name ACVR2A
Gene ID 92
Gene Full Name activin A receptor type 2A
Gene Alias ACVR2; ACTRII
Transcripts ENSG00000121989
Virus HPV
Gene Type protein coding
HPA Location Info Cytosol;
Membrane Info Predicted membrane proteins
HPA Protein Class Info Cancer-related genes, Enzymes, Predicted membrane proteins
Uniport_ID P27037
HGNC ID HGNC:173
VEGA ID OTTHUMG00000150603
OMIM ID 102581
String ID 9606.ENSP00000241416
Drugbank ID BE0003472
PharmGKB ID PA24494
Target gene [ACVR2A] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
5200683 chr2 4 1 5 View
5402718 chr2 1 6 7 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE140662 (GEO) Condyloma Acuminatum 8 Condyloma acuminata (HPV+)(5), Skin(3)
GSE65858 (GEO) Head and neck squamous cell carcinoma 270 Head and neck squamous cell carcinoma (EBV+)(73), Head and neck squamous cell carcinoma (EBV-)(197)
GSE55546 (GEO) Oropharyngeal squamous cell carcinoma 16 Oropharyngeal cancers (HPV+)(12), Normal (4)
GSE55544 (GEO) Oropharyngeal squamous cell carcinoma 23 Oropharyngeal cancers HPV Active (11), Oropharyngeal cancers HPV Inactive (4), Oropharyngeal cancers HPV Negative (8)
GSE55542 (GEO) Oropharyngeal squamous cell carcinoma 36 Oropharyngeal cancers HPV Active (12), Oropharyngeal cancers HPV Inactive (8), Oropharyngeal cancers HPV Negative (16)
GSE138080 (GEO) Cervical intraepithelial neoplasia 25 Normal (10), Cervical intraepithelial neoplasia (HPV+)(15)
GSE51993 (GEO) Cervical intraepithelial neoplasia 24 Cervical intraepithelial neoplasia (HPV+)(17), Normal(7)
HNSC (TCGA) Head and Neck squamous cell carcinoma 566 Head and Neck squamous cell carcinoma(HPV-)(483),Head and Neck squamous cell carcinoma(HPV+)(39),Paracancerous(HPV-)(44)

> Dataset: GSE140662

HeatMap of cell type fractions in all samples Lollipop of ACVR2A expression and immune infiltrating cell level correlation result in HPV+ samples
ACVR2A expression: Low -> High

> Dataset: GSE65858

HeatMap of cell type fractions in all samples Lollipop of ACVR2A expression and immune infiltrating cell level correlation result in HPV+ samples
ACVR2A expression: Low -> High

> Dataset: GSE55546

HeatMap of cell type fractions in all samples Lollipop of ACVR2A expression and immune infiltrating cell level correlation result in HPV+ samples
ACVR2A expression: Low -> High

> Dataset: GSE55544

HeatMap of cell type fractions in all samples Lollipop of ACVR2A expression and immune infiltrating cell level correlation result in HPV+ samples
ACVR2A expression: Low -> High

> Dataset: GSE55542

HeatMap of cell type fractions in all samples Lollipop of ACVR2A expression and immune infiltrating cell level correlation result in HPV+ samples
ACVR2A expression: Low -> High

> Dataset: GSE138080

HeatMap of cell type fractions in all samples Lollipop of ACVR2A expression and immune infiltrating cell level correlation result in HPV+ samples
ACVR2A expression: Low -> High

> Dataset: GSE51993

HeatMap of cell type fractions in all samples Lollipop of ACVR2A expression and immune infiltrating cell level correlation result in HPV+ samples
ACVR2A expression: Low -> High

> Dataset: HNSC

HeatMap of cell type fractions in all samples Lollipop of ACVR2A expression and immune infiltrating cell level correlation result in HPV+ samples
ACVR2A expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).