HBV Target gene Detail Information

> ACVR1B Gene Search Result

Gene Information

Gene Name	ACVR1B
Gene ID	91
Gene Full Name	activin A receptor type 1B
Gene Alias	ALK4; SKR2; ACTRIB; ACVRLK4
Transcripts	ENSG00000135503
Virus	HBV
Gene Type	protein coding
HPA Location Info	Cytosol;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID	P36896
HGNC ID	HGNC:172
VEGA ID	OTTHUMG00000167920
OMIM ID	601300
String ID	9606.ENSP00000442656
Drugbank ID	BE0000665
Drug (Cytoscape Annotation)	Dasatinib;Crizotinib
PharmGKB ID	PA24493

Target gene [ACVR1B] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
1007467	chr12	24	3		27	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
LIHC (TCGA)	Liver hepatocellular carcinoma	424	Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: LIHC
HeatMap of cell type fractions in all samples	Lollipop of ACVR1B expression and immune infiltrating cell level correlation result in HBV+ samples
ACVR1B expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).