HBV Target gene Detail Information

> ACVR1B Gene Search Result


Gene Information
Gene Name ACVR1B
Gene ID 91
Gene Full Name activin A receptor type 1B
Gene Alias ALK4; SKR2; ACTRIB; ACVRLK4
Transcripts ENSG00000135503
Virus HBV
Gene Type protein coding
HPA Location Info Cytosol;
Membrane Info Predicted membrane proteins
HPA Protein Class Info Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID P36896
HGNC ID HGNC:172
VEGA ID OTTHUMG00000167920
OMIM ID 601300
String ID 9606.ENSP00000442656
Drugbank ID BE0000665
Drug (Cytoscape Annotation) Dasatinib;Crizotinib
PharmGKB ID PA24493
Target gene [ACVR1B] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1007467 chr12 24 3 27 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of ACVR1B expression and immune infiltrating cell level correlation result in HBV+ samples
ACVR1B expression: Low -> High

Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).