HIV Target gene Detail Information

> ACTN4 Gene Search Result

Gene Information

Gene Name	ACTN4
Gene ID	81
Gene Full Name	actinin alpha 4
Gene Alias	FSGS; FSGS1; ACTININ-4
Transcripts	ENSG00000282844
Virus	HIV
Gene Type	protein coding
HPA Location Info	Actin filaments;Nuclear bodies;Cytosol;
HPA Protein Class Info	Disease related genes, Plasma proteins, Predicted intracellular proteins
Gene Function	Oncogene
Uniport_ID	O43707
HGNC ID	HGNC:166
VEGA ID	OTTHUMG00000137382
OMIM ID	604638
String ID	9606.ENSP00000252699
PharmGKB ID	PA23

Target gene [ACTN4] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4000076	chr19	109	557	600	1266	View
4000968	chr19	57	129	51	237	View
4009875	chr19	9	1		10	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of ACTN4 expression and immune infiltrating cell level correlation result in HIV+ samples
ACTN4 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of ACTN4 expression and immune infiltrating cell level correlation result in HIV+ samples
ACTN4 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).