HTLV1 Target gene Detail Information

> ACTG1 Gene Search Result

Gene Information

Gene Name	ACTG1
Gene ID	71
Gene Full Name	actin gamma 1
Gene Alias	ACT; ACTG; DFNA20; DFNA26; HEL-176
Transcripts	ENSG00000184009
Virus	HTLV1
Gene Type	protein coding
HPA Location Info
HPA Protein Class Info	Disease related genes, Plasma proteins, Predicted intracellular proteins
Uniport_ID	P63261
HGNC ID	HGNC:144
VEGA ID	OTTHUMG00000177955
OMIM ID	102560
String ID	9606.ENSP00000458162
Drugbank ID	BE0004938; BE0005013
PharmGKB ID	PA24468

Target gene [ACTG1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6100017	chr17	1034	141	19	1194	View
6100191	chr17	746	74	5	825	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of ACTG1 expression and immune infiltrating cell level correlation result in HTLV1+ samples
ACTG1 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of ACTG1 expression and immune infiltrating cell level correlation result in HTLV1+ samples
ACTG1 expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of ACTG1 expression and immune infiltrating cell level correlation result in HTLV1+ samples
ACTG1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).